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This xpp file was used for the simulations in D. Mears, N. F. Sheppard, Jr., I. Atwater, E. Rojas, R. Bertram, and A. Sherman. 1997. Evidence that calcium release-activated current mediates transient glucose-induced electrical activity in the pancreatic beta-cell. J. Membr. Bio., 155:47-59. [PubMed].

The paper experimentally tested the prediction of CRAC_I that depletion of the ER in basal glucose was responsible for the transient first phase of electrical activity when glucose is elevated.

biphase.ode