Below are xpp files for R. Bertram, L. Satin, M. Zhang, P. Smolen, and A. Sherman. 2004. Calcium and glycolysis mediate multiple bursting modes in pancreatic islets, Biophys. J., 87:3074-3087. [PubMed]
The model exhibits complex oscillations of calcium and membrane potential based on interactions of glycolytic and ionic mechanisms.
See also the following papers in which such models are electrically coupled:
M. G. Pedersen, R. Bertram, and A. Sherman. 2005. Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion, Biophys. J., 89:107-119. [PubMed]
and coupled by diffusion of metabolites:
K. Tsaneva-Atanasova, C. L. Zimliki, R. Bertram, and A. Sherman, 2006. Diffusion of calcium and metabolites in pancreatic islets: Killing oscillat ions with a pitchfork, Biophys. J., 90:3434–3446. [PubMed]
XPP files by figure
-
Stand-Alone Glycolysis Model (Figures 2, 10) (Adapted from Smolen, JTB, 174:137-148 1995, [PubMed]) [glyconly.ode]
-
Fast Electrical Bursting (Figure 3) [Fig3.ode]
-
Compound Bursting (Figure 5) [Fig5.ode]
-
Accordion Bursting (Figure 6) [Fig6.ode]
-
Slow Glycolytic Bursting (Figure 7) [Fig7.ode]
-
Subthreshold Glycolytic Oscillations (Figure 8) [Fig8.ode]
Master file
Combined Model (Choose File/Get set to get all the above patterns.)