Supplementary files for C. S. Nunemaker, R. Bertram, A. Sherman, K. Tsaneva-Atanosova, C. R. Daniel, and L. S. Satin. 2006. Glucose modulates Ca2+ oscillations in pancreatic islets via ionic and glycolytic mechanisms, Biophys. J., 91:2082 - 2096. [Pubmed]

The models in this paper show that the diverse responses to glucose seen in pancreatic islets can be accounted for by a model combining glycolytic and ionic (calcium) mechanisms.

XPP files by figure

• Fast Oscillation; reduction in silent phase (Figure 9A) [FIG9A.ode]
• Fast Oscillation; increase in active phase (Figure 9B) [FIG9B.ode]
• Slow Oscillation (Figure 10A) [FIG10A.ode]
• Compound Oscillation (Figure 10B) [FIG10B.ode]
• Regime Change: Increase in glucose converts from fast electrical to slow metabolic (Figure 11) [FIG11.ode]
• Reverse Regime Change: Model predicts that lowering glucose converts fast electrical to slow metabolic (confirmed experimentally in Fig. 12C, D in paper) (Figure 12A, B) [FIG12A.ode]

Thanks to Camille Daniel for preparing the xpp files.