The xpp files below are for J. P. McKenna, J. Ha, M. J. Merrins, L. S. Satin, A. Sherman, and R. Bertram. 2016. Ca2+ Effects on ATP Production and Consumption Have Key Regulatory Roles on Oscillatory Islet Activity. Biophys. J., 110(3):733-742.[PubMed]
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The original Dual Oscillator Model (DOM) [Fig2.ode]
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The modified DOM with Ca-dependent PDH [Fig3.ode]
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The modified DOM with Ca-dependent PDH [Fig5A_left.ode]
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The modified DOM with Ca-dependent PDH [Fig5A_right.ode]
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The modified DOM with Ca-dependent PDH, diazoxide simulation [Fig6.ode]
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The modified DOM with Ca-dependent PDH, PFKm knockout simulation, [Fig7A.ode]
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The modified DOM with Ca-dependent PDH, KIC knockout simulation, [Fig7B.ode]