T2D Pathogenesis Model

This is supplementary material for J. Ha, L. S. Satin and A. S. Sherman. 2016. Mathematical Model of the Pathogenesis, Prevention and Reversal of Type 2 Diabetes. Endocrinology, 157(2):624-635. PubMed

Readme File (pdf)

Zip archive of all files

XPP source files by figure:

• ZDF.ode (Model for female ZDF rats, used for Figs. 3, 4 and 6)

• human.ode(Model for humans, used for Figs. 7 and 8)

XPP set files for individual figures:

• fig3_ZDF.set (Figure 3: Successful compensation for insulin resistance)
• fig3_ZDF_nogamma.set (Figure 3: Impaired compensation for insulin resistance when gamma is held fixed - no adjustment of KATP channels)
• fig4_ZDF.set (Figure 4: Failure of compensation for insulin resistance)
• fig6_ZDF_LFD.set (Figure 6: Maintained normoglycemia in female rats on low fat diet)
• fig6_ZDF_HFD.set (Figure 6: Development of diabetes in female rats on high fat diet)
• fig7_human_early.set (Figure 7: Reversal of diabetes in human subject by intervention in early stage of T2D)
• fig7_human_late.set (Figure 7: Failure to reverse diabetes in human subject by intervention in late stage of the disease)
• fig7_human_prevention.set (Figure 7: Prevention of diabetes in human subject by very early intervention that halts progression of insulin resistance)
• fig8_human.set (Figure 8: Reversal of diabetes in human subject by bariatric surgery)