Pituitary cell model using a common core of ionic currents

Two XPP files, described below, reproduce model trajectories described in:

“Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells” by Fletcher, Sherman, and Stojilkovic, Molecular and Cellular Endocrinology, 463:23–36, 2018. 10.1016/j.mce.2017.06.022

The ODE files below can be downloaded and run using Bard Ermentrout’s XPPAUT simulation tool

MCE17a.ode

This ODE file can be used to reproduce trajectories in Figures 2 and 6

Figure 2

Change (gBK, gNaV) as follows:

• top - (0.9, 15)
• middle - (0.6, 1)
• bottom - (0.02, 12)

Figure 6

Make sure the system is at steady state before applying a pulse stimulus to exactly recreate the figure.

Modify paramter values as follows:

• All panels - gBK=1
• top - gNav=1, ggsp=0.15
• middle - gNav=15, ggsp=0.15
• bottom - gNab=0.2, ggirk=2

MCE17b.ode

Pituitary cell model using a common core of ionic currents, modified to include ER calcium, a cytosolic calcium subspace, and IP3 receptor dynamics. This file can be used to reproduce Figure 7

Figure 7

Modify parameter values as follows:

• left panel: sigmad=39, ip3p=0.22, ggqp=0.15
• right panel: sigmad=1, ip3p=0.5, ggqp=0.15